| Date | Location | Result | |
| 02/25/06 | Long Center, Scranton, Pa. | The University of Scranton 64, Wilkes University 63 | Box score |
| 2/22/06 | Wilkes-Barre, Pa. | Wilkes University 68, King's 61 | Box score |
| 2/18/06 | Baldwin Gym | Wilkes Colonels 70, Drew University Rangers 55 | Box score |
| 2/14/06 | Wilkes-Barre, Pa. | King's 69, Wilkes University 66 | Box score |
| 02/11/06 | Wilkes-Barre, PA | Wilkes University 88, FDU-Florham 61 | Box score |
| 02/08/06 | Long Center, Scranton, Pa. | The University of Scranton 65, Wilkes University 52 | Box score |
| 02/04/06 | Doylestown, PA | Delaware Valley 93, Wilkes University 84 | Box score |
| 02/01/06 | Wilkes-Barre, PA | Lycoming College 77, Wilkes University 69 | Box score |
| 01/28/06 | Wilkes-Barre, PA | DeSales University 85, Wilkes University 74 | Box score |
| 1/25/06 | Madison, NJ Ferguson Rec Center | Wilkes 55, FDU-Florham 43 | Box score |
| 01/21/06 | Wilkes-Barre, PA | Wilkes University 78, Drew University 59 | Box score |
| 01/18/06 | Williamsport, Pa. | WIL 64, Lycoming College 52 | Box score |
| 01/14/06 | Wilkes-Barre, PA | Wilkes University 89, Delaware Valley College 42 | Box score |
| 01/11/06 | Wilkes-Barre, PA | Wilkes University 64, University of Scranton 58 | Box score |
| 01/08/06 | Wilkes-Barre, PA | Susquehanna University 81, Wilkes University 79 | Box score |
| 01/07/06 | Wilkes-Barre, PA | Keystone College 78, Wilkes University 65 | Box score |
| 01/04/06 | Scranton, PA | Marywood University 63, Wilkes University 61 | Box score |
| 12/12/05 | Wilkes-Barre, PA | Wilkes University 107, Lincoln University 99 | Box score |
| 12/7/05 | Immaculata, PA | Wilkes University 74, Immaculata College 58 | Box score |
| 12/03/05 | Center Valley, PA - Billera Hall | Wilkes University 71, DeSales University 68 | Box score |
| 11/30/05 | Wilkes-Barre, PA | Wilkes University 77, King's College 76 | Box score |
| 11/22/05 | Wilkes-Barre, PA (Marts Center) | Wilkes University 82, Baptist Bible College 68 | Box score |
| 11/19/05 | Potsdam, NY Alumni Gymnasium | Wilkes University 95, Paul Smith's College 39 | Box score |
| 11/18/05 | Potsdam, NY | Potsdam State 68, Wilkes University 55 | Box score |